Name： Shao Chin Lee
Qualification：PhD (The University of Auckland)
Position： Distinguished Professor
Phone：18535146037
E-mail:lee_shao@hotmail.com
Education
BSc,Amoy University, 1983
MMed,The First Medical University of PLA, 1986
PhD,The University of Auckland, 1999
Employment
2018-：Distinguished Professor, Jiangsu Normal University
2014-：Distinguished Professor, Shanxi University
2011-2013：Assistant Professor, Chinese University of Hong Kong
2003-2010：Principal Investigator, National University of Singapore
1997-2002：Resaerch Associate, Chinese University of Hong Kong
1991-1992：Postgrad Investigator, The University of Queensland
1989-1991：Visiting Investigator, The University of Sydney
1986-1989：Assistant Lecturer, The First Medical University of PLA
Current research Focus
1.The biological ink between type 2 diabetes and cancer
2.Molecular mechanisms underlying diabetes-associated centrosome amplification
3.Therapeutic development of natural products for cancer
4.Cell signal transduction pathways
Major academic achievement
No. of SCI paper：38, with 60% at tier 2 or 1. No. of student graduated：8 PhD 10 MSc. No. of patent：7. No. of international award：3.International conference：10 times as committee member and 4 times as section chair. Reviewer for 9 international journals.
Major academic contribution
1.Localization of the hemochromatosis gene close to D6S105；
2.Discovery of evidence for genetic anticipation in type 2 diabetes；
3.Discovery of evidence for paternal effect in type 2 diabetes；
4.Discovery of cell centrosome amplification in type 2 diabetes
Research grant
Ongoing project
1.Jiangsu Normal University, direct grant, Centrosome amplification in type 2 daibetes and the molecular mechanisms,2018/5-2022/4, 900000 RMB, PI
Completed project
1.Department of Science and Technology of Shanxi Province, Centrosome amplification：biological link between type 2 diabetes and cancer, 1016/07-2018/12, 30000RMB, PI
2.Department of Science and Technology of Shanxi Province, Molecular mechanisms underlying diabetes-associated centrosome amplification, 2015/05-2017/05, 100000 RMB, PI
3.Shanxi University, Centrosome amplification in type 2 diabetes, 2014/04-2019/04, 1300000 RMB, PI
4.Chinese University of Hong Kong, Exploration of the molecular mechanisms of cancer cell proliferation promoted by hyperglycemia, 2012/06-2013/06, 50000 HKD, PI
5.National Medical Research Fund of Singapore, NMRC0969/2005, Characterizing the resveratrol-evoked，Bax- and p53-independent apoptosis signaling cascades: in relevance to the therapeutic development of resveratrol in treating drug-resistant cancers, 2005/06-2009/05, 202000 SGD, PI
6.National University of Singapore Research Fund, Delineation of resveratro-evoked apoptosis signaling pathways, 2007/08-2010/07, 190000 SGD, PI
7.National Medical Research Fund of Singapore, NMRC/EDG/0007/2007, Glucose-evoked renal cell death and underlying molecular mechanisms: in relevance to the development of diabetic nephropathy, 2007/12-2009/12, 190000 SGD, PI
8.Sanofi fund, Roles of hyperglycemia and oxidative stress on gene expression implicated in cancer pathways in type 2 diabetes, 2012/02-2013/123, 832000 HKD, Co-I
9.HK RGC，Establishment of a catalogue of Chinese-specific genetic markers for obesity, diabetes and diabetic kidney disease, 2000/08-2003/01, 4473000 HKD, Co-I
10.HK industrial fund，Establishment of a catalogue of Chinese-specific genetic markers for obesity, diabetes and diabetic kidney disease, 2000/08-2003/01, 500000 HKD, Co-I
11.CUHK，Spatial redistribution of signaling molecules following insulin stimulation in rat skeletal muscle cells, 2001/06-2002/05, 57000 HKD, Co-I
12.CUHK,Spatial redistribution of signaling molecules following insulin stimulation in rat skeletal muscle cells, 2001/06-2002/05, 57000 HKD, Co-I
13.CUHK, Mapping genes for young onset diabetes, obesity and disbetic nephropathy, 1999/01-2001/12, 500000 HKD, Co-I
14.CUHK, Hormonal interaction in the determination of obesity and insulin resistance in the metabolic syndrome, 2000/10-2001/10, 60000 HKD, Co-I
【Paper】
*: corresponding author; 60 % at tier 1 or 2
A: Tier 1
1.Lang L, Zhang Z, Jing W, Hwang JS, Lee SC*, Wang L. Identification of a novel toll gene (Shtoll3) from the freshwater crab Sinopotamon henanense and its expression pattern changes in response to cadmium followed by Aeromonas hydrophila infection.Fish Shellfish Immunol. 71:177-190, 2017
2.Lee SC*, Chan J, Pervaiz S. Spontaneous and 5-fluorouracil-evoked centrosome amplification lowers the threshold to resveratrol-induced apoptosis in colon cancer cells. Cancer Lett. 288:36-41, 2010
3.Lee SC*, Ko GTC, Li JKY, Chow CC, Yeung VTF, Critchley JAJH, Cockram CS, Chan JCN. Factors predicting the age at diagnosis of type 2 diabetes in Hong Kong Chinese. Diabetes Care 24:646-649, 2001
4.Ng MC, Lee SC, Ko GT, Li JK, So WY, Hashim Y, Barnett AH, Mackay IR, Critchley JA, Cockram CS, Chan JC. Familial early-onset type 2 diabetes in Chinese patients: obesity and genetics have more significant roles than autoimmunity. Diabetes Care 24:663-671, 2001
5.Lee SC*, Pu YB, Chow CC, Yeung VTF, Ko GTC, So WY, Li JKY, Chan WB, Ma RCW, Critchley JAJH, Cockram CS and Chan JCN. Diabetes in Hong Kong Chinese: Familial clustering and parental effects. Diabetes Care 23:1365-1368, 2000
6.Wang Y, Ng MC, Lee SC, So WY, Tong PC, Cockram CS, Critchley JA, Chan JC. Phenotypic heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes. Diabetes Care. 26:2410-2415, 2003
7.Jazwinska EC, Pyper WR, Burt MJ, Francis JC, Goldwurm S, Webb SI, Lee SC, Halliday JW and Powell LW. Haplotype analysis in Australian hemochromatosis patients: Evidence for a predominant ancestral haplotype exclusively associated with hemochromatosis. Am J Hum Genet 56:428-433, 1995
8.Jazwinska EC, Lee SC, Webb SI, Halliday JW and Powell LW. Localization of hemochromatosis gene close to D6S105. Am J Hum Genet 53:347-352, 1993
B: Tier 2
1.Liu QQ, Wang P, He QJ, Ma R, Lee SC*. PPARγ promotes diabetes-associated centrosome amplification via increasing the expression of SKA1 directly at the transcriptional level. J Cell Physiol. doi: 10.1002/jcp.28674, 2019
2.Zhang RK, Wang P, Lu YC, Lang L, Wang L, Lee SC*. Cadmium induces cell centrosome amplification via reactive oxygen species as well as endoplasmic reticulum stress pathway. J Cell Physiol. doi: 10.1002/jcp.28455, 2019
3.Lu YC, Wang P, Wu QG, Zhang RK, Kong A, Li YF, Lee SC*. Hsp74/14-3-3σ Complex Mediates Centrosome Amplification by High Glucose, Insulin, and Palmitic Acid. Proteomics. doi: 10.1002/pmic.201800197, 2019
4.Lu YC, Wang P, Wang J, Ma R, Lee SC*. PCNA and JNK1-Stat3 pathways respectively promotes and inhibits diabetes-associated centrosome amplification by targeting at the ROCK1/14-3-3σ complex in human colon cancer HCT116 cells. J Cell Physiol. 234:11511-11523, 2019
5.Wang P, Lu YC, Wang J, Wang L, Yu H, Li YF, Kong A, Chan J, Lee SC*. Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3σ. Cell Physiol Biochem. 47:356-367, 2018
6.Huo J, Dong A, Wang Y, Lee SC*, Ma C, Wang L. Cadmium induces histopathological injuries and ultrastructural changes in the liver of freshwater. Chemosphere. 186:459-465, 2017
7.Huo J, Dong A, Yan J, Wang L, Ma C, Lee SC*. Cadmium toxicokinetics in the freshwater turtle, Chinemys reevesii. Chemosphere. 182:392-398, 2017
8.Yang Y, Zhang Y, Wang L, Lee S*. Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells. Cell Physiol Biochem. 42:929-938, 2017
9.Lee SC*, Sim N, Clement M, Yadav S, Pervaiz S. Dominant negative Rac1N17 attenuates human melanoma M14 cell apoptosis sensitivity by upregulation of heat shock protein 27: a functional proteomic study. Proteomics. 7:4112-4122, 2007
10.Lee SC*, Pervaiz S. Apoptosis in the pathogenesis of diabetes mellitus Int J Biochem Cell Biol. 39:497-504, 2007
11.Lee SC* Chan J, Clement M, Pervaiz S. Functional proteomic analysis of resveratrol-evoked colon cancer cell apoptosis: caspase-6 cleavage of lamin A is a major signalling loop. Proteomics. 6:2386-94,2006
12.Lee SC*, Wang Y, Ko GTC, Critchley JAJH, Cockram, CS and Chan JCN. Risks factors for cataract in Chinese patients with type 2 diabetes: Evidence for the influence of the aldose reductase gene. Clin Genet 59:356-359, 2001
13.Lee SC*, Hashim, Y. Li JKY, Ko GTC, Critchley JAJH, Cockram CS and Chan JCN. The islet amyloid polypeptide (amylin) gene S20G mutation in Chinese subjects: Evidence for associations with Type 2 diabetes and cholesterol levels Clin Endocr 54:541-546, 2001
14.Lee SC*, Pu YB, Thomas NG, Critchley JAJH, Thomlinson B, Cockram CS and Chan JCN. Tumor necrosis factor gene G-308A polymorphism in the metabolic syndrome. Metab-clinical and experimental 49:1021-1024, 2000
C:Tier 3 and Tier 4
1.Wang P, Liu Q, Lee SC*. Diabetes-associated oxidative damage to DNA base in colon cells. Acta Biochim Biophys Sin (Shanghai). doi: 10.1093/abbs/gmz010, 2019
2.Wang P, Lu YC, Li YF, Wang L, Lee SC*. Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5. J Diabetes Res. 2018:3274084, 2018
3.Huo J, Dong A, Niu X, Dong A, Lee S*, Ma C, Wang L. Effects of cadmium on oxidative stress activities in plasma of freshwater turtle Chinemys reevesii. Environ Sci Pollut Res Int. 25:8027-8034, 2018
4.Liu J, Wang J, Lee SC, Wen R. Copper-caused oxidative stress triggers the activation of antioxidant enzymes via ZmMPK3 in maize leaves. PLoS One. 13:e0203612， 2018
5.Li B, Li D, Jing W, Fan J, Dahms HU, Lee SC*, Wang L. Biogenic selenium and its hepatoprotective activity. Sci Rep. 7:15627, 2017
6.Liu N, Yang HL, Wang P, Lu YC, Yang YJ, Wang L, Lee SC*. Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway. J Ethnopharmacol. 189:210-217, 2016
7.Wang P, Yang HL, Yang YJ, Wang L, Lee SC*. Overcome cancer cell drug resistance using natural products. Evid Based Complement Alternat Med. 2015:767136, 2015
8.Lee SC*, Chan JC.Evidence for DNA damage as a biological link between diabetes and cancer. Chin Med J (Engl). 128:1543-1548, 2015
9.Sun M, Li YT, Liu Y, Lee SC and Wang L. Transcriptome assembly and expression profiling of molecular responses to cadmium toxicity in hepatopancreas of the freshwater crab Sinopotamon henanense. Sci Rep. doi:10.1038/srep19405, 2015
10.Wang Y, Luk AO, Ng MC, Pang CC, Lam V, Lee SC, Lam DS, Choy KW, Ma RC, So WY, Chan JC. Additive effect of aldose reductase Z-4 microsatellite polymorphism and glycaemic control on cataract development in type 2 diabetes. J Diabetes Complications. 28:147-51, 2014
11.Lee SC*, Chan J. Proteomic identification of TCP-1 gamma as p53 responsive protein. Cancer Genomics and Proteomics. 9:101-108, 2012
12.Chan J, Benny Tan, Lee SC*. Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation. Anticancer Res. 29:3043-3047, 2009
13.Chan J, Phoo R, Clement M, Pervaiz S, Lee SC*. Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53. Cancer Bio & Therapy. 7:1-8, 2008
14.Ko GT, Lee SC, Pu YB, Ng MC, So WY, Thomas N, Chan WB, Cockram CS, Chan JC. Tumour necrosis factor-alpha promoter gene polymorphism at - 308 (genotype AA) in Chinese subjects with Type 2 diabetes. Diabet Med. 20:167-168, 2003
15.Lee SC*, Cooper GJS. Amylin evokes protein p20 phosphorylation and insulin resistance in rat skeletal muscle extensor digitorum longus. Sci China. 45:159-165, 2002.
16.Chan JCN, Ng M, Critchley JAJH, Lee SC, Cockram CS. Diabetes mellitus-a special medical challenge from a Chinese perspective. Diabetes Res Clin Pract 54 (Suppl 1):19-27, 2001
【Patent】
1.YJ Yang, SC Lee, L Wang. Levistolide A as a sensitizer for colon cancer chemotherapy. China, 2018
2.J Critchley, SC Lee, C Cockram, J Chan. Genomic markers for determination of risk for diabetes. China, 2002
3.J Critchley, SC Lee, C Cockram, J Chan. Genomic markers for determination of risk for diabetes.Hong Kong SAR, 2002
4.J Critchley, SC Lee, C Cockram, J Chan. Genomic markers for determination of risk for diabetes. Macau SAR, 2002
5.J Critchley, SC Lee, C Cockram, J Chan. Genomic markers for determination of risk for cataract.China, 2000
6.J Critchley, SC Lee, C Cockram, J Chan. Genomic markers for determination of risk for cataract.Macau, 2000
7.J Critchley, SC Lee, C Cockram, J Chan. Genomic markers for determination of risk for cataract. Hong Kong SAR, 2000
【International award】
1.Yong Scientist Award, International Union of Biochemistry and Molecular Biology, 1997
2.Invited Membership, American Association for the Advancement of Science, 1997
3. Second Prize, The International Association for the Study of the Liver, 1992
