Shaohua Fan, PhD
University Professor/Doctoral Supervisor
Email：fshfly@126.com
Education
Ph.D., Oncology, Shanghai Jiao Tong University
M.S., Biochemistry and Molecular Biology,Fujian Agriculture and Forestry University
B.S., Biology, Hebei University
Professional experience
2004-present：School of Life Sciences, Jiangsu Normal University
Research interests
1.Functions of oncogenes and related genes
2.Screening of anticancer drugs from flavonoids
Work performance
I won the following individual awards: “Three Aspects of Education” Advanced Individual of Jiangsu Normal University; Teaching Excellence Award of Jiangsu Normal University; Outstanding Communist Party Member of Jiangsu Normal University; Advanced Worker of Jiangsu Normal University. I have published some papers in Oncogene, Free Radical Biology & Medicine and other SCI journals, and presided over the projects of the National Natural Science Foundation of China and the Natural Science Foundation for Colleges and Universities in Jiangsu Province.
Research grants
1. Role and mechanism of LASS2 in hepatocellular carcinoma occurrence and development by using a liver-specific knockout mouse model, National Natural Science Foundation of China, Grant number: 81672731, Role: Principal Investigator.
2. Effect and mechanism of LPCAT1 on multidrug resistance of breast cancer cells, Natural Science Foundation for Colleges and Universities in Jiangsu Province, Grant number: 12KJB320001, Role: Principal Investigator.
3. Role and mechanism of AGPAT9 in multidrug resistance of breast cancer cells, Scientific Research Support Project for Teachers with Doctor’s Degrees (Class A), Grant number: 13XLR045, Role: Principal Investigator.
Publications
1. Ning Sheng, Yanyan Wang, Ying Xie, Sihan Chen, Jun Lu, Zifeng Zhang, Mengqiu Li, Qun Shan, Dongmei Wu, Guihong Zheng, Yuanlin Zheng, Shaohua Fan* (*corresponding author). High expression of LASS2 is associated with unfavorable prognosis in patients with ovarian cancer. J Cell Physiol, 2019, 234(8):13001-13013.
2. Yanyan Wang, Ning Sheng, Ying Xie, Sihan Chen, Jun Lu, Zifeng Zhang, Qun Shan, Dongmei Wu, Guihong Zheng, Mengqiu Li, Yuanlin Zheng, Shaohua Fan* (*corresponding author). J Cell Physiol, 2019, 234(8):13629-13638.
3. Shaohua Fan* (*corresponding author), et al. Low expression of ENC1 predicts a favorable prognosis in patients with ovarian cancer. J Cell Biochem, 2019, 120(1):861-871.
4. Shaohua Fan, et al. Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic steatosis and insulin resistance. Free Radic Biol Med, 2018, 120:330-341.
5. Shaohua Fan, et al. High expression of glutamate-ammonia ligase is associated with unfavorable prognosis in patients with ovarian cancer. J Cell Biochem, 2018, 119(7): 6008-6015.
6. Shaohua Fan, et al. AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer. Oncotarget, 2015, 6(21):18406-18417.
7. Shaohua Fan, et al. CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer. J Cell Biochem, 2015, 116(4):502-513.
8. Shaohua Fan, et al. Luteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of NLRP3 inflammasome. PLoS One, 2014, 9(2):e89961.
9. Shaohua Fan, et al. LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump. Oncogene, 2013, 32(13):1682-1690.
10. Shaohua Fan, et al. Purple sweet potato color attenuates D-galactose-induced renal injury in mice by inhibiting the expression of NF-κB-dependent inflammatory genes. J Med Plants Res, 2012, 6(21):3694-3704.
11. Shaohua Fan, et al. Troxerutin protects the mouse kidney from D-galactose-caused injury through anti-inflammation and anti-oxidation. Int Immunopharmacol, 2009, 9(1):91-96.
12. Shaohua Fan (Co-first author), et al. GLUL promotes cell proliferation in breast cancer. J Cell Biochem, 2017, 118(8):2018-2025.
13. Shaohua Fan (Co-first author), et al. Gas6/Axl axis contributes to chemoresistance and metastasis in breast cancer through Akt/GSK-3β/β-catenin signaling. Theranostics, 2016, 6(8):1205-1219.
14. Shao-hua Fan (Co-first author), et al. Troxerutin protects the mouse liver against oxidative stress-mediated injury induced by D-galactose. J Agric Food Chem, 2009, 57(17):7731-7736.
